Page 50 - Škrgat, Sabina, ed. 2023. Severe Asthma Forum - Monitoring and Treatable Traits in Severe Asthma. Koper: University of Primorska Press. Severe Asthma Forum, 2
P. 50
um and can be a trigger for bronchial hyper- lustrative cytokines. Int J Mol Sci.
activity26,27. From the above, polysomnogra- 2019 Jan 22;20(3):459. doi: 10.3390/
severe asthma forum 2: severe asthma - monitoring and treatable traits in severe asthma ijms20030459.
phy is recommended for asthma patients with 3. ten Brinke A. Risk factors of frequent
inadequate control of night symptoms despite exacerbations in difficult-to-treat
proper treatment28. asthma. Eur Respirat J. 2005
Nov;26(5):812-8.
Mortality in patients with OSA and 4. Pepito DL, Mohammed JM, Hardin
asthma is poorly researched. In one study, KA. Obstructive Sleep Apnea and Asth-
it was shown that patients with asthma and ma: More Than Chance?. Curr Pulmo-
sleep disorders have a higher risk of mortal- nol Rep. 2021 Mar 12;10(9):84-91.
ity compared to asthma patients without 5. Ragnoli B, Pochetti P, Raie A, et al.
sleep disorders29. In patients with asthma and Interrelationship Between Obstruc-
O SA, CPAP treatment reduces asthma symp- tive Sleep Apnea Syndrome and Se-
toms, improves morning expiratory flow, and vere Asthma: From Endo-Phenotype
improves quality of life parameters30. In one to Clinical Aspects. Front Med (Lau-
prospective study, it was shown that the pro- sanne). 2021 Jun 30:8:640636. doi:
portion of adult patients with uncontrolled 10.3389/fmed.2021.640636.
asthma dropped from 41.4 to 17.2% with 6. Auckley D, Moallem M, Shaman Z,
CPAP treatment. It was also shown that the et al. Findings of a Berlin Question-
proportion of patients who had worsening naire survey: comparison between pa-
asthma decreased from 35.4 to 17.2% after tients seen in an asthma clinic versus
six months of CPAP machine use7. internal medicine clinic. Sleep Med.
2008;9(5):494-9.
Conclusion 7. Serrano-Pariente J, Plaza V, Soriano
JB, et al. CPASMA Trial Group. Asth-
The association between OSA and severe ma outcomes improve with continuous
asthma is based on coincident pathophysi- positive airway pressure for obstructive
ological mechanisms, bidirectional interac- sleep apnea. Allergy. 2017;72(5):802-12.
tions and the presence of similar comorbidi- 8. Lafond C, Sériès F, Lemière C. Impact
ties. Similar to asthma, OSA also promotes an of CPAP on asthmatic patients with ob-
inflammatory response through hypoxia and structive sleep apnoea. Eur. Respir. J.
hypercapnia and sleep fragmentation leading 2007;29(2):307-11.
to an irreversible increase in C reactive pro- 9. Franklin KA, Lindberg E. Obstructive
tein, tumor necrosis factor and other proin- sleep apnea is a common disorder in the
flammatory cytokines involved in airway col- population-a review on the epidemiol-
lapse and hyperreactivity. Proinflammatory ogy of sleep apnea. J Thorac Dis. 2015
factors tend to decrease when these patients Aug;7(8):1311-22.
are treated with a CPAP device, which leads 10. American Academy of Sleep Medicine.
to improvement in asthma symptoms and a International classification of sleep dis-
better quality of life. orders. 3rd ed. Darien, IL: American
Academy of Sleep Medicine, 2014. 383
References p.
11. Damianaki A, Vagiakis E, Sigala I, et
1. Lin C-C, Lin C-Y. Obstructive sleep ap- al. The co-existence of obstructive sleep
nea syndrome and bronchial hyperreac- apnea and bronchial asthma: revela-
tivity. Lung. 1995;173(2):117-26. tion of a new asthma phenotype? J Clin
2. Kheirandish-Gozal L, Gozal D. Ob-
structive sleep apnea and inflamma-
tion: proof of concept based on two il-
activity26,27. From the above, polysomnogra- 2019 Jan 22;20(3):459. doi: 10.3390/
severe asthma forum 2: severe asthma - monitoring and treatable traits in severe asthma ijms20030459.
phy is recommended for asthma patients with 3. ten Brinke A. Risk factors of frequent
inadequate control of night symptoms despite exacerbations in difficult-to-treat
proper treatment28. asthma. Eur Respirat J. 2005
Nov;26(5):812-8.
Mortality in patients with OSA and 4. Pepito DL, Mohammed JM, Hardin
asthma is poorly researched. In one study, KA. Obstructive Sleep Apnea and Asth-
it was shown that patients with asthma and ma: More Than Chance?. Curr Pulmo-
sleep disorders have a higher risk of mortal- nol Rep. 2021 Mar 12;10(9):84-91.
ity compared to asthma patients without 5. Ragnoli B, Pochetti P, Raie A, et al.
sleep disorders29. In patients with asthma and Interrelationship Between Obstruc-
O SA, CPAP treatment reduces asthma symp- tive Sleep Apnea Syndrome and Se-
toms, improves morning expiratory flow, and vere Asthma: From Endo-Phenotype
improves quality of life parameters30. In one to Clinical Aspects. Front Med (Lau-
prospective study, it was shown that the pro- sanne). 2021 Jun 30:8:640636. doi:
portion of adult patients with uncontrolled 10.3389/fmed.2021.640636.
asthma dropped from 41.4 to 17.2% with 6. Auckley D, Moallem M, Shaman Z,
CPAP treatment. It was also shown that the et al. Findings of a Berlin Question-
proportion of patients who had worsening naire survey: comparison between pa-
asthma decreased from 35.4 to 17.2% after tients seen in an asthma clinic versus
six months of CPAP machine use7. internal medicine clinic. Sleep Med.
2008;9(5):494-9.
Conclusion 7. Serrano-Pariente J, Plaza V, Soriano
JB, et al. CPASMA Trial Group. Asth-
The association between OSA and severe ma outcomes improve with continuous
asthma is based on coincident pathophysi- positive airway pressure for obstructive
ological mechanisms, bidirectional interac- sleep apnea. Allergy. 2017;72(5):802-12.
tions and the presence of similar comorbidi- 8. Lafond C, Sériès F, Lemière C. Impact
ties. Similar to asthma, OSA also promotes an of CPAP on asthmatic patients with ob-
inflammatory response through hypoxia and structive sleep apnoea. Eur. Respir. J.
hypercapnia and sleep fragmentation leading 2007;29(2):307-11.
to an irreversible increase in C reactive pro- 9. Franklin KA, Lindberg E. Obstructive
tein, tumor necrosis factor and other proin- sleep apnea is a common disorder in the
flammatory cytokines involved in airway col- population-a review on the epidemiol-
lapse and hyperreactivity. Proinflammatory ogy of sleep apnea. J Thorac Dis. 2015
factors tend to decrease when these patients Aug;7(8):1311-22.
are treated with a CPAP device, which leads 10. American Academy of Sleep Medicine.
to improvement in asthma symptoms and a International classification of sleep dis-
better quality of life. orders. 3rd ed. Darien, IL: American
Academy of Sleep Medicine, 2014. 383
References p.
11. Damianaki A, Vagiakis E, Sigala I, et
1. Lin C-C, Lin C-Y. Obstructive sleep ap- al. The co-existence of obstructive sleep
nea syndrome and bronchial hyperreac- apnea and bronchial asthma: revela-
tivity. Lung. 1995;173(2):117-26. tion of a new asthma phenotype? J Clin
2. Kheirandish-Gozal L, Gozal D. Ob-
structive sleep apnea and inflamma-
tion: proof of concept based on two il-
