Page 53 - Petelin, Ana. 2021. Ed. Zdravje starostnikov / Health of the Elderly. Proceedings. Koper: University of Primorska Press.
P. 53
Conclusions the effect of non-nutritive sweeteners on lipid metabolism in liver cells 51
Treatment of liver cells with the selected non-nutritive sweeteners did not re-
flect in altered lipid accumulation. The observed changes in gene expression,
however, point to their important impact on lipid metabolism. As genes relat-
ed to the beta-oxidation as well as those related to the fat storage were up-regu-
lated, long-term effects should be further investigated to confirm their safe use
in terms of liver health.
References
BUTCHKO, H.H., STARGEL, W.W., COMER, C.P., MAYHEW, D.A., BEN-
NINGER, C., BLACKBURN, G.L., DE SONNEVILLE, L.M.J., GEHA,
R.S., HERTELENDY, Z., KOESTNER, A. et al., 2002. Aspartame: Re-
view of Safety. Regulatory Toxicology and Pharmacology. April 2002.
Vol. 35, no. 2, p. S1–S93. [viewed 13 July 2021]. Available from: http://dx.
doi.org/10.1006/rtph.2002.1542.
GREEN, C.H. and SYN, W-K, 2019. Non-nutritive sweeteners and their associ-
ation with the metabolic syndrome and non-alcoholic fatty liver disease:
a review of the literature. European Journal of Nutrition. August 2019.
Vol. 58, no. 5, p. 1785–1800. [viewed 13 July 2021]. Available from: http://
dx.doi.org/10.1007/s00394-019-01996-5.
LEBDA, M.A., TOHAMY, H.G. and EL-SAYED, Y.S., 2017. Long-term soft
drink and aspartame intake induces hepatic damage via dysregulation
of adipocytokines and alteration of the lipid profile and antioxidant sta-
tus. Nutrition Research. May 2017. Vol. 41, p. 47–55. [viewed 13 July 2021].
Available from: http://dx.doi.org/10.1016/j.nutres.2017.04.002.
MA, J., FOX, C.S., JACQUES, P.F., SPELIOTES, E.K., HOFFMANM, U.,
SMITH, C.E., McKEOWN, N.M., 2015. Sugar-sweetened beverage, di-
et soda, and fatty liver disease in the Framingham Heart Study cohorts.
Journal of Hepatology, Vol. 63(2), p. 462–469. Available from: https://doi.
org/10.1016/j.jhep.2015.03.032
PEPINO, M. Y., 2015. Metabolic effects of non-nutritive sweeteners. Physiol-
ogy & Behavior, Vol. 152(Pt B), p. 450–455. Available from: https://doi.
org/10.1016/j.physbeh.2015.06.024
SCHIFFMAN, S.S., 2012. Rationale for Further Medical and Health Research
on High-Potency Sweeteners. Chemical Senses. October 2012. Vol. 37,
no. 8, p. 671–679. [viewed 13 July 2021]. Available from: http://dx.doi.
org/10.1093/chemse/bjs053.
SWITHERS, S.E, 2016. Not-so-healthy sugar substitutes? Current Opinion in
Behavioral Sciences. June 2016. Vol. 9, p. 106–110. Available from: http://
dx.doi.org/10.1016/j.cobeha.2016.03.003.
SYLVETSKY, A.C. and ROTHER, K.I., 2016. Trends in the consump-
tion of low-calorie sweeteners. Physiology & Behavior. October 2016.
Vol. 164, p. 446–450. [viewed 13 July 2021]. Available from: http://dx.doi.
org/10.1016/j.physbeh.2016.03.030
Treatment of liver cells with the selected non-nutritive sweeteners did not re-
flect in altered lipid accumulation. The observed changes in gene expression,
however, point to their important impact on lipid metabolism. As genes relat-
ed to the beta-oxidation as well as those related to the fat storage were up-regu-
lated, long-term effects should be further investigated to confirm their safe use
in terms of liver health.
References
BUTCHKO, H.H., STARGEL, W.W., COMER, C.P., MAYHEW, D.A., BEN-
NINGER, C., BLACKBURN, G.L., DE SONNEVILLE, L.M.J., GEHA,
R.S., HERTELENDY, Z., KOESTNER, A. et al., 2002. Aspartame: Re-
view of Safety. Regulatory Toxicology and Pharmacology. April 2002.
Vol. 35, no. 2, p. S1–S93. [viewed 13 July 2021]. Available from: http://dx.
doi.org/10.1006/rtph.2002.1542.
GREEN, C.H. and SYN, W-K, 2019. Non-nutritive sweeteners and their associ-
ation with the metabolic syndrome and non-alcoholic fatty liver disease:
a review of the literature. European Journal of Nutrition. August 2019.
Vol. 58, no. 5, p. 1785–1800. [viewed 13 July 2021]. Available from: http://
dx.doi.org/10.1007/s00394-019-01996-5.
LEBDA, M.A., TOHAMY, H.G. and EL-SAYED, Y.S., 2017. Long-term soft
drink and aspartame intake induces hepatic damage via dysregulation
of adipocytokines and alteration of the lipid profile and antioxidant sta-
tus. Nutrition Research. May 2017. Vol. 41, p. 47–55. [viewed 13 July 2021].
Available from: http://dx.doi.org/10.1016/j.nutres.2017.04.002.
MA, J., FOX, C.S., JACQUES, P.F., SPELIOTES, E.K., HOFFMANM, U.,
SMITH, C.E., McKEOWN, N.M., 2015. Sugar-sweetened beverage, di-
et soda, and fatty liver disease in the Framingham Heart Study cohorts.
Journal of Hepatology, Vol. 63(2), p. 462–469. Available from: https://doi.
org/10.1016/j.jhep.2015.03.032
PEPINO, M. Y., 2015. Metabolic effects of non-nutritive sweeteners. Physiol-
ogy & Behavior, Vol. 152(Pt B), p. 450–455. Available from: https://doi.
org/10.1016/j.physbeh.2015.06.024
SCHIFFMAN, S.S., 2012. Rationale for Further Medical and Health Research
on High-Potency Sweeteners. Chemical Senses. October 2012. Vol. 37,
no. 8, p. 671–679. [viewed 13 July 2021]. Available from: http://dx.doi.
org/10.1093/chemse/bjs053.
SWITHERS, S.E, 2016. Not-so-healthy sugar substitutes? Current Opinion in
Behavioral Sciences. June 2016. Vol. 9, p. 106–110. Available from: http://
dx.doi.org/10.1016/j.cobeha.2016.03.003.
SYLVETSKY, A.C. and ROTHER, K.I., 2016. Trends in the consump-
tion of low-calorie sweeteners. Physiology & Behavior. October 2016.
Vol. 164, p. 446–450. [viewed 13 July 2021]. Available from: http://dx.doi.
org/10.1016/j.physbeh.2016.03.030
