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loads/2019/04/GINA-Severe-asthma- 22. Azim A, Freeman A, Lavenu A, et al.
Pocket-Guide-v2.0-wms-1.pdf. New Perspectives on Difficult Asthma;
severe asthma forum 1: severe asthma - basic and clinical views 14. Asthma UK. Living in limbo: the scale Sex and Age of Asthma-Onset Based
of unmet need in difficult and severe Phenotypes. J Allergy Clin Immunol
asthma [Internet]. Report. [place un- Pract. 2020 Nov-Dec;8(10):3396-406.
known]: Asthma UK; 2019. 20 p. Avail- e04.
able from: https://www.asthma.org.
uk/69841483/globalassets/get-in- 23. Agusti A, Bel E, Thomas M, et al.
volved/external-affairs-campaigns/ Treatable traits: toward precision med-
publications/living-in-limbo/living-in- icine of chronic airway diseases. Eur
limbo---the-scale-of-unmet-need-in- Respir J. 2016 Feb;47(2):410-9.
difficult-and-severe-asthma.pdf.
15. O’Neill S, Sweeney J, Patterson CC, et 24. Freitas PD, Xavier RF, McDon-
al. The cost of treating severe refractory ald VM, et al. Identification of asth-
asthma in the UK: an economic anal- ma phenotypes based on extrapul-
ysis from the British Thoracic Socie- monary treatable traits. Eur Respir
ty Difficult Asthma Registry. Thorax. J. 2021 Jan 21;57(1):2000240. doi:
2015 Apr;70(4):376-8. 10.1183/13993003.00240-2020.
16. Tay TR, Hew M. Comorbid “treatable
traits” in difficult asthma: Current evi- 25. McDonald VM, Hiles SA, Godbout K,
dence and clinical evaluation. Allergy. et al. Treatable traits can be identified
2018 Jul;73(7):1369-82. in a severe asthma registry and predict
17. Tay TR, Radhakrishna N, Hore-Lacy future exacerbations. Respirology. 2019
F, et al. Comorbidities in difficult asth- Jan;24(1):37-47.
ma are independent risk factors for fre-
quent exacerbations, poor control and 26. Simpson AJ, Hekking PP, Shaw DE,
diminished quality of life. Respirology. et al. Treatable traits in the European
2016 Nov;21(8):1384-90. U-BIOPRED adult asthma cohorts. Al-
18. Chung KF, Wenzel SE, Brozek JL, et lergy. 2019 Feb;74(2):406-11.
al. International ERS/ATS guidelines
on definition, evaluation and treatment 27. Tay TR, Lee J, Radhakrishna N, et al.
of severe asthma. Eur Respir J. 2014 A Structured Approach to Specialist-re-
Feb;43(2):343-73. ferred Difficult Asthma Patients Im-
19. von Bülow A, Backer V, Bodtger U, et proves Control of Comorbidities and
al. Differentiation of adult severe asth- Enhances Asthma Outcomes. J Al-
ma from difficult-to-treat asthma – lergy Clin Immunol Pract. 2017 Jul-
Outcomes of a systematic assessment Aug;5(4):956-964.e3.
protocol. Respir Med. 2018 Dec;145:41-
7. 28. McDonald VM, Clark VL, Cordo-
20. Hekking PW, Wener RR, Amelink M, va-Rivera L, et al. Targeting treat-
et al. The prevalence of severe refrac- able traits in severe asthma: a ran-
tory asthma. J Allergy Clin Immunol. domised controlled trial. Eur Respir
2015 Apr;135(4):896-902. J. 2020 Mar 5;55(3):1901509. doi:
21. Pavord ID, Beasley R, Agusti A, et al. 10.1183/13993003.01509-2019.
After asthma: redefining airways dis-
eases. Lancet. 2018 Jan;391(10118):350- 29. NHS England. Specialised respirato-
400. ry services (adult) – Severe asthma [In-
ternet]. Service specification for special-
ised respiratory services in adults. [place
unknown]: NHS England; 2017 [cit-
ed 2021 Aug]. Available from: https://
www.england.nhs.uk/publication/spe-
cialised-respiratory-services-adult-se-
vere-asthma/.
Pocket-Guide-v2.0-wms-1.pdf. New Perspectives on Difficult Asthma;
severe asthma forum 1: severe asthma - basic and clinical views 14. Asthma UK. Living in limbo: the scale Sex and Age of Asthma-Onset Based
of unmet need in difficult and severe Phenotypes. J Allergy Clin Immunol
asthma [Internet]. Report. [place un- Pract. 2020 Nov-Dec;8(10):3396-406.
known]: Asthma UK; 2019. 20 p. Avail- e04.
able from: https://www.asthma.org.
uk/69841483/globalassets/get-in- 23. Agusti A, Bel E, Thomas M, et al.
volved/external-affairs-campaigns/ Treatable traits: toward precision med-
publications/living-in-limbo/living-in- icine of chronic airway diseases. Eur
limbo---the-scale-of-unmet-need-in- Respir J. 2016 Feb;47(2):410-9.
difficult-and-severe-asthma.pdf.
15. O’Neill S, Sweeney J, Patterson CC, et 24. Freitas PD, Xavier RF, McDon-
al. The cost of treating severe refractory ald VM, et al. Identification of asth-
asthma in the UK: an economic anal- ma phenotypes based on extrapul-
ysis from the British Thoracic Socie- monary treatable traits. Eur Respir
ty Difficult Asthma Registry. Thorax. J. 2021 Jan 21;57(1):2000240. doi:
2015 Apr;70(4):376-8. 10.1183/13993003.00240-2020.
16. Tay TR, Hew M. Comorbid “treatable
traits” in difficult asthma: Current evi- 25. McDonald VM, Hiles SA, Godbout K,
dence and clinical evaluation. Allergy. et al. Treatable traits can be identified
2018 Jul;73(7):1369-82. in a severe asthma registry and predict
17. Tay TR, Radhakrishna N, Hore-Lacy future exacerbations. Respirology. 2019
F, et al. Comorbidities in difficult asth- Jan;24(1):37-47.
ma are independent risk factors for fre-
quent exacerbations, poor control and 26. Simpson AJ, Hekking PP, Shaw DE,
diminished quality of life. Respirology. et al. Treatable traits in the European
2016 Nov;21(8):1384-90. U-BIOPRED adult asthma cohorts. Al-
18. Chung KF, Wenzel SE, Brozek JL, et lergy. 2019 Feb;74(2):406-11.
al. International ERS/ATS guidelines
on definition, evaluation and treatment 27. Tay TR, Lee J, Radhakrishna N, et al.
of severe asthma. Eur Respir J. 2014 A Structured Approach to Specialist-re-
Feb;43(2):343-73. ferred Difficult Asthma Patients Im-
19. von Bülow A, Backer V, Bodtger U, et proves Control of Comorbidities and
al. Differentiation of adult severe asth- Enhances Asthma Outcomes. J Al-
ma from difficult-to-treat asthma – lergy Clin Immunol Pract. 2017 Jul-
Outcomes of a systematic assessment Aug;5(4):956-964.e3.
protocol. Respir Med. 2018 Dec;145:41-
7. 28. McDonald VM, Clark VL, Cordo-
20. Hekking PW, Wener RR, Amelink M, va-Rivera L, et al. Targeting treat-
et al. The prevalence of severe refrac- able traits in severe asthma: a ran-
tory asthma. J Allergy Clin Immunol. domised controlled trial. Eur Respir
2015 Apr;135(4):896-902. J. 2020 Mar 5;55(3):1901509. doi:
21. Pavord ID, Beasley R, Agusti A, et al. 10.1183/13993003.01509-2019.
After asthma: redefining airways dis-
eases. Lancet. 2018 Jan;391(10118):350- 29. NHS England. Specialised respirato-
400. ry services (adult) – Severe asthma [In-
ternet]. Service specification for special-
ised respiratory services in adults. [place
unknown]: NHS England; 2017 [cit-
ed 2021 Aug]. Available from: https://
www.england.nhs.uk/publication/spe-
cialised-respiratory-services-adult-se-
vere-asthma/.
