Page 129 - Petelin, Ana, Nejc Šarabon, eds. 2018. Zdravje starostnikov ▪︎ Health of the Elderly. Zbornik povzetkov z recenzijo ▪︎ Book of Abstracts. Koper: Založba Univerze na Primorskem/University of Primorska Press
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ects of physical inactivity on inflammation telesna (ne)aktivnost in njen pomen ... | physical (in)activity and its importance ...
Mihaela Jurdana1, Ana Petelin1, Nina Mohorko1, Tadeja Jakus1, Rado Pišot2,
Boštjan Šimunič2, Zala Jenko Pražnikar1
1 University of Primorska, Faculty of health Sciences, Polje 42, 6310 Izola, Slovenia
2 Science and Research Centre Koper, Garibaldijeva 1, 6000 Koper, Slovenia
Introduction: Studies in elderly and young people generally support anti-in-
flammatory effects of physical activity and moderate exercise. We hypothe-
sized that complete physical inactivity could affect the pro- and anti-inflamma-
tory markers differently in elderly and young participants.
Methods: Complete physical inactivity has been used as a model in both groups
of healthy male volunteers: 7 young (aged 18–30) and 16 older adults (aged 55–
65). The effects of inactivity on inflammation were compared. Key low-grade
inflammation mediators, tumour necrosis factor α (TNF-α), interleukin-6 (IL-
6), visfatin, resistin, and anti-inflammatory adiponectin were measured before
and after prolong inactivity.
Results: Young responded to inactivity by increasing serum visfatin and resis-
tin while older adults responded by increasing IL-6 and TNF-α. In addition, se-
rum adiponectin increased in all participants. Correlation analysis demonstrat-
ed positive association between serum visfatin and IL-6 in both groups, while
serum adiponectin was negatively associated with TNF-α in young and posi-
tively associated with resistin in the older adults.
Discussion and conclusions: Short-term complete physical inactivity negatively
affected markers of low-grade inflammation in both groups, but the inflamma-
tion was more pronounced in older adults. This supports the notion that elder-
ly people should avoid even short periods of physical inactivity.
Keywords: physical inactivity, inflammation, adipokines, elderly
127
Mihaela Jurdana1, Ana Petelin1, Nina Mohorko1, Tadeja Jakus1, Rado Pišot2,
Boštjan Šimunič2, Zala Jenko Pražnikar1
1 University of Primorska, Faculty of health Sciences, Polje 42, 6310 Izola, Slovenia
2 Science and Research Centre Koper, Garibaldijeva 1, 6000 Koper, Slovenia
Introduction: Studies in elderly and young people generally support anti-in-
flammatory effects of physical activity and moderate exercise. We hypothe-
sized that complete physical inactivity could affect the pro- and anti-inflamma-
tory markers differently in elderly and young participants.
Methods: Complete physical inactivity has been used as a model in both groups
of healthy male volunteers: 7 young (aged 18–30) and 16 older adults (aged 55–
65). The effects of inactivity on inflammation were compared. Key low-grade
inflammation mediators, tumour necrosis factor α (TNF-α), interleukin-6 (IL-
6), visfatin, resistin, and anti-inflammatory adiponectin were measured before
and after prolong inactivity.
Results: Young responded to inactivity by increasing serum visfatin and resis-
tin while older adults responded by increasing IL-6 and TNF-α. In addition, se-
rum adiponectin increased in all participants. Correlation analysis demonstrat-
ed positive association between serum visfatin and IL-6 in both groups, while
serum adiponectin was negatively associated with TNF-α in young and posi-
tively associated with resistin in the older adults.
Discussion and conclusions: Short-term complete physical inactivity negatively
affected markers of low-grade inflammation in both groups, but the inflamma-
tion was more pronounced in older adults. This supports the notion that elder-
ly people should avoid even short periods of physical inactivity.
Keywords: physical inactivity, inflammation, adipokines, elderly
127
