Page 49 - Petelin, Ana, in Helena Skočir. 2020. Ur. Raziskovanje za znanje, znanje za zdravje. Zbornik prispevkov z recenzijo. Koper: Založba Univerze na Primorskem.
P. 49
ljuček nina lapornik, mihaela jurdana, mojca stubelj
Pravočasno odkrivanje bolnikov, ki so v fazi prekaheksije in kaheksije, vodi
do učinkovitejšega zdravljenja. Ob ugotovitvi podhranjenosti je treba bol-
nika takoj vključiti v prehransko svetovanje in mu nuditi prehransko podpo-
ro tudi s prehranskimi dopolnili. Raziskave na področju zdravljenja kaheksije
so usmerjene v različna področja prehranskih dopolnil, z vplivom na kahek-
sijo. Velik potencial imajo prehranska dopolnila, ki vsebujejo več različnih se
stavin, saj ima vsaka od njih posebno funkcijo. Pri imuno prehrani so to ar-
ginin, omega-3-MK in nukleotidi, v encimski formuli Ethanwell/Ethanzyme
pa glutamin, selen, koencim Q10 in encimski produkti iz probiotikov in vita-
minov. Tudi L-karnitin, glicin in BCAA lahko vplivajo na telesno maso ali zavi-
rajo vnetno citokinsko delovanje.
Literatura
ARENDS, J., BACHMANN, P., BARACOS, V., BARTHELEMY, N., BERTZ, H., BOZZETTI, F., FEA-
RON, K., HÜTTERERG, E., ISENRING, E., KAASA, S. et al., 2017. ESPEN guidelines on nutri-
tion in cancer patients [online]. Clinical Nutrition, vol. 36, (1), 11–48. Pridobljeno 23. 2.
2020 s https://doi.org/10.1016/j.clnu.2016.07.015
ARGILÉS, J. M., BUSQUETS, S. in LÓPEZ-SORIANO, F. J., 2011. Anti-inflammatory therapies
in cancer cachexia [online]. European Journal of Pharmacology, Pharma-Nutrition, vol.
668, (S1), str. 81–86. Pridobljeno 23. 2. 2020 s https://doi.org/10.1016/j.ejphar.2011.07.007
ASSI, M., DERBRÉ, F., LEFEUVRE-ORFILA, L. in RÉBILLARD, A., 2016. Antioxidant
supplementation accelerates cachexia development by promoting tumor growth in
C26 tumor-bearing mice [online]. Free Radical Biology and Medicine, vol. 91, str. 204–
214. Pridobljeno 23. 2. 2020 s https://doi.org/10.1016/j.freeradbiomed.2015.12.019
BAUER, J., 2007. Nutritional Management and Dietary Guidelines for Cancer Cachexia
[online]. European oncological disease, 1(2), 12–14. Pridobljeno 23. 2. 2020 s http://doi.
org/10.17925/EOH.2007.0.2.12
BINDELS, L. B. in THISSEN, J-P., 2016. Nutrition in Cancer Patients with Cachexia: A Role for
the Gut Microbiota [online]? Clinical Nutrition Experimental, vol. 6, str. 74–82. Pridoblje-
no 23. 2. 2020 s https://doi.org/10.1016/j.yclnex.2015.11.001
CRUZ, B., OLIVEIRA, A. In GOMES-MARCONDES, M. C. C., 2017. L-leucine dietary supple-
mentation modulates muscle protein degradation and increases pro-inflammatory
cytokines in tumour-bearing rats [online]. Cytokine, vol. 96, str. 253–260. Pridobljeno
23. 2. 2020 s https://doi.org/10.1016/j.cyto.2017.04.019
DAS, S. K.in HOEFLER, G., 2013. The Role of Triglyceride Lipases in Cancer Associated Ca-
chexia [online]. Trends in Molecular Medicine, vol. 19, (5), str. 292–301. Pridobljeno 23. 2.
2020 s https://doi.org/10.1016/j.molmed.2013.02.006
DE CAMPOS-FERRAZ, P. L., ANDRADE, I., DAS NEVES, W., HANGAI, I., ALVES, C. R. R. in LAN-
CHA JR., A. H., 2014. An Overview of Amines as Nutritional Supplements to Counte-
ract Cancer Cachexia [online]. Journal of Cachexia, Sarcopenia and Muscle, vol. 5, (2), str.
105–110. Pridobljeno 23. 2. 2020 s https://doi.org/10.1007/s13539-014-0138-x
DU, L., XU, J., XUE, Y., TAKAHASHI, K., XUE, C-H., WANG, J-F. in WANG, Y-M., 2015. Cerebrosi-
des from sea cucumber ameliorates cancer-associated cachexia in mice by attenua-
ting adipose atrophy [online]. Journal of functional foods, vol. 17, str. 352–363. Pridobl-
jeno 23. 2. 2020 s https://doi.org/10.1016/j.jff.2015.05.040
47
Pravočasno odkrivanje bolnikov, ki so v fazi prekaheksije in kaheksije, vodi
do učinkovitejšega zdravljenja. Ob ugotovitvi podhranjenosti je treba bol-
nika takoj vključiti v prehransko svetovanje in mu nuditi prehransko podpo-
ro tudi s prehranskimi dopolnili. Raziskave na področju zdravljenja kaheksije
so usmerjene v različna področja prehranskih dopolnil, z vplivom na kahek-
sijo. Velik potencial imajo prehranska dopolnila, ki vsebujejo več različnih se
stavin, saj ima vsaka od njih posebno funkcijo. Pri imuno prehrani so to ar-
ginin, omega-3-MK in nukleotidi, v encimski formuli Ethanwell/Ethanzyme
pa glutamin, selen, koencim Q10 in encimski produkti iz probiotikov in vita-
minov. Tudi L-karnitin, glicin in BCAA lahko vplivajo na telesno maso ali zavi-
rajo vnetno citokinsko delovanje.
Literatura
ARENDS, J., BACHMANN, P., BARACOS, V., BARTHELEMY, N., BERTZ, H., BOZZETTI, F., FEA-
RON, K., HÜTTERERG, E., ISENRING, E., KAASA, S. et al., 2017. ESPEN guidelines on nutri-
tion in cancer patients [online]. Clinical Nutrition, vol. 36, (1), 11–48. Pridobljeno 23. 2.
2020 s https://doi.org/10.1016/j.clnu.2016.07.015
ARGILÉS, J. M., BUSQUETS, S. in LÓPEZ-SORIANO, F. J., 2011. Anti-inflammatory therapies
in cancer cachexia [online]. European Journal of Pharmacology, Pharma-Nutrition, vol.
668, (S1), str. 81–86. Pridobljeno 23. 2. 2020 s https://doi.org/10.1016/j.ejphar.2011.07.007
ASSI, M., DERBRÉ, F., LEFEUVRE-ORFILA, L. in RÉBILLARD, A., 2016. Antioxidant
supplementation accelerates cachexia development by promoting tumor growth in
C26 tumor-bearing mice [online]. Free Radical Biology and Medicine, vol. 91, str. 204–
214. Pridobljeno 23. 2. 2020 s https://doi.org/10.1016/j.freeradbiomed.2015.12.019
BAUER, J., 2007. Nutritional Management and Dietary Guidelines for Cancer Cachexia
[online]. European oncological disease, 1(2), 12–14. Pridobljeno 23. 2. 2020 s http://doi.
org/10.17925/EOH.2007.0.2.12
BINDELS, L. B. in THISSEN, J-P., 2016. Nutrition in Cancer Patients with Cachexia: A Role for
the Gut Microbiota [online]? Clinical Nutrition Experimental, vol. 6, str. 74–82. Pridoblje-
no 23. 2. 2020 s https://doi.org/10.1016/j.yclnex.2015.11.001
CRUZ, B., OLIVEIRA, A. In GOMES-MARCONDES, M. C. C., 2017. L-leucine dietary supple-
mentation modulates muscle protein degradation and increases pro-inflammatory
cytokines in tumour-bearing rats [online]. Cytokine, vol. 96, str. 253–260. Pridobljeno
23. 2. 2020 s https://doi.org/10.1016/j.cyto.2017.04.019
DAS, S. K.in HOEFLER, G., 2013. The Role of Triglyceride Lipases in Cancer Associated Ca-
chexia [online]. Trends in Molecular Medicine, vol. 19, (5), str. 292–301. Pridobljeno 23. 2.
2020 s https://doi.org/10.1016/j.molmed.2013.02.006
DE CAMPOS-FERRAZ, P. L., ANDRADE, I., DAS NEVES, W., HANGAI, I., ALVES, C. R. R. in LAN-
CHA JR., A. H., 2014. An Overview of Amines as Nutritional Supplements to Counte-
ract Cancer Cachexia [online]. Journal of Cachexia, Sarcopenia and Muscle, vol. 5, (2), str.
105–110. Pridobljeno 23. 2. 2020 s https://doi.org/10.1007/s13539-014-0138-x
DU, L., XU, J., XUE, Y., TAKAHASHI, K., XUE, C-H., WANG, J-F. in WANG, Y-M., 2015. Cerebrosi-
des from sea cucumber ameliorates cancer-associated cachexia in mice by attenua-
ting adipose atrophy [online]. Journal of functional foods, vol. 17, str. 352–363. Pridobl-
jeno 23. 2. 2020 s https://doi.org/10.1016/j.jff.2015.05.040
47
