Page 207 - Petelin, Ana. 2020. Zdravje delovno aktivne populacije / Health of the Working-Age Population. Zbornik povzetkov z recenzijo ▪︎ Book of Abstracts. Koper: Založba Univerze na Primorskem/University of Primorska Press
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chemical and hematological parameters in determination posterji | poster presentations
of renal disease: effects on work ability
Damir Suljević, Lejla Klepo, Muhamed Fočak
Faculty of Science, Department of Biology, Zmaja od Bosne 33, 71000 Sarajevo,
Bosna in Hercegovina
Introduction: Hemodialysis is common modality used to treat advanced and
chronic kidney disease as a great public health problem, especially in devel-
oping countries. The progression of kidney damage is marked by the rise in
concentration of several biochemical and hematological parameters whose
evaluation contribute in renal function assessment. Hemodialysis affects many
aspects of human life: functioning in society, work ability and general health sta-
tus. The main aim of this research was to determine significant differencies in
concentration of biochemical and hematological parameters in patients on he-
modialysis.
Methods: This study included 25 patients with renal complications on hemo-
dialysis (patients with early stage of renal disease (ES, n=15) and patients with
late stage of renal disease (LS, n=10). Complete blood count, hemoglobin con-
centration and hematological indexes (MCV, MCHC and MCH) were deter-
mined using Siemens Advia 120 hematological analyzer, while concentration
of biochemical parameters (urea, creatinine, uric acid, total proteins and K+)
were measured using autoanalyser Pentra 200 LabTajm LTD. An anonymous
questionnaire was distributed to patients and 19 out of 25 completed it.
Results: Significant changes between patients with early and late stage of re-
nal disease for concentration of following biochemical parameters were found:
urea (xE̅ S=16.53 mmol/l, xL̅ S=31.36 mmol/l; p<0.05), creatinine (xE̅ S=594.60
µmol/l, xL̅ S=1369.95 µmol/l; p<0.05), uric acid (xE̅ S=267.70 µmol/l,
xL̅ S=501.73 µmol/l; p<0.05) and K+ (xE̅ S=4.71 mmol/l, xL̅ S=6.20 mmol/l;
p<0.05) concentrations. Among hematological parameters, significant differ-
ence was found only for MCH values (xE̅ S=31.04 pg, xL̅ S=33.52 pg; p<0.05).
Out of 25 patients, 15 of them were employed (private or public sector). The
answers in the questionnaire showed that 35% of patients could not give their
maximum at work, and 21% of them were stigmatized in a certain way in socie-
ty and/or on work. In addition, only 12% responded that they had encountered
a maximum understanding of their employer becuse of their health condition.
Discussion and conclusions: Our results showed that biochemical parameters
are more sensitive compared to hematological parameters for detection of
renal disease stage in patients on hemodialysis. By measuring blood values of
these compounds, assessment of the renal excretory functions can be done
and therefore levels of biochemical and hematological parameters can also be
used as a diagnostic tool in assessment of renal diseases stage. This type of re-
search should motivate and encourage students and scientists who are dealing
with this area to perform further research and to raise up awareness of kid-
ney disease in different aspects of life. Potentially, support groups in any form
would be of great importance in overcoming the stigmatization of patients on
hemodialysis.
Key words: biochemical parameters, hemodialysis, renal disease
205
of renal disease: effects on work ability
Damir Suljević, Lejla Klepo, Muhamed Fočak
Faculty of Science, Department of Biology, Zmaja od Bosne 33, 71000 Sarajevo,
Bosna in Hercegovina
Introduction: Hemodialysis is common modality used to treat advanced and
chronic kidney disease as a great public health problem, especially in devel-
oping countries. The progression of kidney damage is marked by the rise in
concentration of several biochemical and hematological parameters whose
evaluation contribute in renal function assessment. Hemodialysis affects many
aspects of human life: functioning in society, work ability and general health sta-
tus. The main aim of this research was to determine significant differencies in
concentration of biochemical and hematological parameters in patients on he-
modialysis.
Methods: This study included 25 patients with renal complications on hemo-
dialysis (patients with early stage of renal disease (ES, n=15) and patients with
late stage of renal disease (LS, n=10). Complete blood count, hemoglobin con-
centration and hematological indexes (MCV, MCHC and MCH) were deter-
mined using Siemens Advia 120 hematological analyzer, while concentration
of biochemical parameters (urea, creatinine, uric acid, total proteins and K+)
were measured using autoanalyser Pentra 200 LabTajm LTD. An anonymous
questionnaire was distributed to patients and 19 out of 25 completed it.
Results: Significant changes between patients with early and late stage of re-
nal disease for concentration of following biochemical parameters were found:
urea (xE̅ S=16.53 mmol/l, xL̅ S=31.36 mmol/l; p<0.05), creatinine (xE̅ S=594.60
µmol/l, xL̅ S=1369.95 µmol/l; p<0.05), uric acid (xE̅ S=267.70 µmol/l,
xL̅ S=501.73 µmol/l; p<0.05) and K+ (xE̅ S=4.71 mmol/l, xL̅ S=6.20 mmol/l;
p<0.05) concentrations. Among hematological parameters, significant differ-
ence was found only for MCH values (xE̅ S=31.04 pg, xL̅ S=33.52 pg; p<0.05).
Out of 25 patients, 15 of them were employed (private or public sector). The
answers in the questionnaire showed that 35% of patients could not give their
maximum at work, and 21% of them were stigmatized in a certain way in socie-
ty and/or on work. In addition, only 12% responded that they had encountered
a maximum understanding of their employer becuse of their health condition.
Discussion and conclusions: Our results showed that biochemical parameters
are more sensitive compared to hematological parameters for detection of
renal disease stage in patients on hemodialysis. By measuring blood values of
these compounds, assessment of the renal excretory functions can be done
and therefore levels of biochemical and hematological parameters can also be
used as a diagnostic tool in assessment of renal diseases stage. This type of re-
search should motivate and encourage students and scientists who are dealing
with this area to perform further research and to raise up awareness of kid-
ney disease in different aspects of life. Potentially, support groups in any form
would be of great importance in overcoming the stigmatization of patients on
hemodialysis.
Key words: biochemical parameters, hemodialysis, renal disease
205
