Page 20 - Petelin, Ana. 2020. Ed. Zdravje delovno aktivne populacije / Health of the Working-Age Population. Proceedings. Koper: University of Primorska Press.
P. 20
avje delovno aktivne populacije | health of the working-age population 18 gut microbiota while studying the effect of phenolic compounds on gut micro-
biota modulation from the immunological point of view.
Conclusions
Dietary polyphenols have increasingly interested the scientific community due
to their proposed health benefits. Possible beneficial effects of polyphenols are
determined by their bioavailability where the gut microbiota have an impor-
tant role. Phenolic compounds are biotransformed into their smaller metabo-
lites by gut microbiota, which contributes to increased bioavailability. At the
same time, phenolic compounds can alter the gut microbiota community, re-
sulting in a greater abundance of beneficial microbes, and a consequent in-
crease in bioavailability. Despite the results provided and published over re-
cent years, future studies including human trials will give more confirmatory
results about the efficacy of phenolic compounds at the gut level. These results
may lead to the design of dietary recommendations not only to suppress or re-
duce symptoms in disease but also to provide the healthy population with sim-
ple tools to promote the maintenance of health.
References
Abbas, M., Saeed, F., Anjum, F. M., Afzaal, M., Tufail, T., Bashir, M. S., Ishtiaq,
A., Hussain, S., & Suleria, H. A. R. (2017). Natural polyphenols: An over-
view. International Journal of Food Properties, 20(8), 1689–1699. https://
doi.org/10.1080/10942912.2016.1220393
Bialonska, D., Kasimsetty, S. G., Schrader, K. K., & Ferreira, D. (2009). The ef-
fect of pomegranate (Punica granatum L.) byproducts and ellagitannins
on the growth of human gut bacteria. Journal of Agricultural and Food
Chemistry, 57(18), 8344–8349. https://doi.org/10.1021/jf901931b
Bialonska, D., Ramnani, P., Kasimsetty, S. G., Muntha, K. R., Gibson, G. R., &
Ferreira, D. (2010). The influence of pomegranate by-product and puni-
calagins on selected groups of human intestinal microbiota. Internation-
al Journal of Food Microbiology, 140(2), 175–182. https://doi.org/10.1016/j.ij-
foodmicro.2010.03.038
Burcelin, R., Garidou, L., & Pomié, C. (2012). Immuno-microbiota cross and
talk: The new paradigm of metabolic diseases. Seminars in Immunology,
24(1), 67–74. https://doi.org/10.1016/j.smim.2011.11.011
Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo-Or-
tuño, M. I. (2013). Benefits of polyphenols on gut microbiota and impli-
cations in human health. The Journal of Nutritional Biochemistry, 24(8),
1415–1422. https://doi.org/10.1016/j.jnutbio.2013.05.001
Corrêa, T. A. F., Rogero, M. M., Hassimotto, N. M. A., & Lajolo, F. M. (2019).
The Two-Way Polyphenols-Microbiota Interactions and Their Effects on
biota modulation from the immunological point of view.
Conclusions
Dietary polyphenols have increasingly interested the scientific community due
to their proposed health benefits. Possible beneficial effects of polyphenols are
determined by their bioavailability where the gut microbiota have an impor-
tant role. Phenolic compounds are biotransformed into their smaller metabo-
lites by gut microbiota, which contributes to increased bioavailability. At the
same time, phenolic compounds can alter the gut microbiota community, re-
sulting in a greater abundance of beneficial microbes, and a consequent in-
crease in bioavailability. Despite the results provided and published over re-
cent years, future studies including human trials will give more confirmatory
results about the efficacy of phenolic compounds at the gut level. These results
may lead to the design of dietary recommendations not only to suppress or re-
duce symptoms in disease but also to provide the healthy population with sim-
ple tools to promote the maintenance of health.
References
Abbas, M., Saeed, F., Anjum, F. M., Afzaal, M., Tufail, T., Bashir, M. S., Ishtiaq,
A., Hussain, S., & Suleria, H. A. R. (2017). Natural polyphenols: An over-
view. International Journal of Food Properties, 20(8), 1689–1699. https://
doi.org/10.1080/10942912.2016.1220393
Bialonska, D., Kasimsetty, S. G., Schrader, K. K., & Ferreira, D. (2009). The ef-
fect of pomegranate (Punica granatum L.) byproducts and ellagitannins
on the growth of human gut bacteria. Journal of Agricultural and Food
Chemistry, 57(18), 8344–8349. https://doi.org/10.1021/jf901931b
Bialonska, D., Ramnani, P., Kasimsetty, S. G., Muntha, K. R., Gibson, G. R., &
Ferreira, D. (2010). The influence of pomegranate by-product and puni-
calagins on selected groups of human intestinal microbiota. Internation-
al Journal of Food Microbiology, 140(2), 175–182. https://doi.org/10.1016/j.ij-
foodmicro.2010.03.038
Burcelin, R., Garidou, L., & Pomié, C. (2012). Immuno-microbiota cross and
talk: The new paradigm of metabolic diseases. Seminars in Immunology,
24(1), 67–74. https://doi.org/10.1016/j.smim.2011.11.011
Cardona, F., Andrés-Lacueva, C., Tulipani, S., Tinahones, F. J., & Queipo-Or-
tuño, M. I. (2013). Benefits of polyphenols on gut microbiota and impli-
cations in human health. The Journal of Nutritional Biochemistry, 24(8),
1415–1422. https://doi.org/10.1016/j.jnutbio.2013.05.001
Corrêa, T. A. F., Rogero, M. M., Hassimotto, N. M. A., & Lajolo, F. M. (2019).
The Two-Way Polyphenols-Microbiota Interactions and Their Effects on
